Dor J, Itzkowic D J, Mashiach S, Lunenfeld B, Serr D M
Am J Obstet Gynecol. 1980 Jan 1;136(1):102-5. doi: 10.1016/0002-9378(80)90574-8.
During the years 1963 to 1978, 515 patients were treated with HMG. They were divided into two groups depending upon the absence (Group I) or presence (Group II) of distinct endogenous estrogen activity. Group II patients were referred after failure of clomiphene therapy. None of the patients had mechanical or male infertility factors. The cumulative pregnancy rate (life table method) in Group I patients after six cycles of treatment was 91.2%. In 77 patients from Group I, further treatment was given for a second pregnancy after the first gonadotropin conception. In this group, the cumulative conception rate was 93.6% after eight cycles of treatment. In Group II the cumulative conception rate was 50% after 12 cycles of treatment. In both groups, the results were better in patients who were less than 35 years of age than those who were 35 or more when treated.
1963年至1978年期间，515例患者接受了人绝经期促性腺激素（HMG）治疗。根据是否存在明显的内源性雌激素活性，将他们分为两组（第一组）无活性，（第二组）有活性。第二组患者是在克罗米芬治疗失败后转诊而来的。所有患者均无机械性或男性不育因素。第一组患者经过六个周期治疗后的累积妊娠率（生命表法）为91.2%。第一组的77例患者在首次使用促性腺激素受孕后，为再次妊娠接受了进一步治疗。在该组中，经过八个周期治疗后的累积受孕率为93.6%。第二组在经过12个周期治疗后的累积受孕率为50%。在两组中，年龄小于35岁的患者的治疗结果均优于治疗时年龄在35岁及以上的患者。
