Stout L C, Thorpe L W
Atherosclerosis. 1980 Feb;35(2):165-80. doi: 10.1016/0021-9150(80)90082-9.
Little information is available on the histology of the normal aorta in non-human primates, despite their extensive use in atherosclerosis research. This paper consists of a detailed histologic description of normal aortas from 28 non-human primates, including 20 species. Medial and adventitial coats were essentially normal in all animals, and the former were composed of lamellar units similar in structure to those described in detail by other investigators. Intimal thickenings were present in 24 of the 28 individuals. These thickenings were similar in morphology to those of diffuse intimal thickening (DIT) in humans and other animals, and were more prevalent in older animals and in larger animals. The thickenings were not more prevalent or more pronounced in any particular region of the aorta, and their distribution did not provide a clue as to their etiology. Findings suggested that the thickenings underwent recognizable states of growth and maturation, and that growth was accomplished by the addition of smooth muscle cells at the intimomedial junction.
尽管非人类灵长类动物在动脉粥样硬化研究中被广泛使用，但关于其正常主动脉组织学的信息却很少。本文详细描述了28只非人类灵长类动物（包括20个物种）正常主动脉的组织学特征。所有动物的中膜和外膜基本正常，中膜由结构与其他研究者详细描述的板层单元组成。28只个体中有24只存在内膜增厚。这些增厚在形态上与人类和其他动物的弥漫性内膜增厚（DIT）相似，在老年动物和大型动物中更普遍。增厚在主动脉的任何特定区域都没有更普遍或更明显，其分布也没有为其病因提供线索。研究结果表明，增厚经历了可识别的生长和成熟阶段，并且生长是通过在内膜中膜交界处添加平滑肌细胞来完成的。
