Stout L C, Whorton E B, Vaghela M
Atherosclerosis. 1983 Apr;47(1):1-6. doi: 10.1016/0021-9150(83)90065-5.
The pathogenesis of diffuse intimal thickening (DIT) is not well understood. In animals, it is positively correlated with size, and with the exception of the pig, is thought to involve the proximal more than the distal portions of vessels. DIT is often not visible grossly, so that it's study requires extensive microscopic sampling of tissue. Review of previous studies in animals suggests that microscopic sampling may not have been sufficient to determine exactly where DIT occurs throughout the entire length of a vessel. The present study is a longitudinal step-serial section examination of the entire descending thoracic aorta from 12 adult non-human primates of varying size and species and with varying degrees of DIT as determined previously by more limited cross-section techniques. The findings indicate that DIT is not more pronounced in the proximal versus the distal segments of the vessel, and is not correlated with branch orifices. Review of the literature suggests that DIT may not be a single process, but may vary in pathogenesis from vessel to vessel and from species to species.
弥漫性内膜增厚（DIT）的发病机制尚未完全明确。在动物中，它与血管大小呈正相关，除猪外，一般认为其在血管近端比远端更为常见。DIT通常在大体上不可见，因此对其研究需要对组织进行广泛的显微镜检查取样。回顾以往的动物研究表明，显微镜检查取样可能不足以准确确定DIT在血管全长中的具体发生位置。本研究对12只成年非人类灵长类动物的整个降主动脉进行了纵向阶梯连续切片检查，这些动物大小和物种各异，且之前通过更有限的横截面技术确定了不同程度的DIT。研究结果表明，DIT在血管近端和远端节段中并无更明显差异，且与分支孔无关。文献回顾表明，DIT可能不是单一过程，其发病机制可能因血管和物种的不同而有所差异。
