Jiménez Cardoso J M, Ambrosius Diener K, Martínez Ojeda C, Heinz Wusterhaus A
Bol Med Hosp Infant Mex. 1980 Jan-Feb;37(1):31-42.
A batch of 45 male Wistar rats, weighing 180 to 325 grams, were used in the experiment. Partial hepatectomy was practiced to them and liver biopsies taken at different periods of times: 0 (control) 4, 8, 12, 24, 36, 48, and 72 hours and 45 days. The biopsies were examined at the electron microscope. During liver regeneration, a sequence of morphological changes was detected, having started with an important decrease of cytoplasmic particles, increase of lipids and laminar bodies like myelin. After 24 hours, preparatory changes for cellular regeneration were observed prior to full regeneration which was reached later.
一批45只体重在180至325克之间的雄性Wistar大鼠用于该实验。对它们实施了部分肝切除术，并在不同时间段进行肝脏活检：0（对照）、4、8、12、24、36、48和72小时以及45天。活检样本在电子显微镜下进行检查。在肝脏再生过程中，检测到一系列形态学变化，开始时细胞质颗粒显著减少，脂质和髓鞘样板层小体增加。24小时后，观察到细胞再生的准备性变化，随后才实现完全再生。
