Budillon G, Parrilli G, D'Agostino L, Capuano G, Mazzacca G, Menzies I S
Digestion. 1980;20(1):68-72. doi: 10.1159/000198416.
The effect of intravenous cholecystokinin (CCK) on intestinal permeability in normal subjects and patients after cholecystectomy has been studied by measuring the fraction of orally administered lactulose excreted in the urine. CCK induced a marked increase in lactulose excretion in normal subjects when given in a hyperosmolar solution (49.4 mg lactulose during 5 h rising to 114.3 mg with CCK, p less than 0.001). CCK failed to affect lactulose excretion when given to normal subjects in an isosmolar solution, and also when given to post-cholecystectomy patients in either hyper- or isosmolar solutions. The 'CCK effect' is therefore related to gallbladder emptying. It is suggested that conjugated bile acids released following gallbladder contraction can affect intestinal permeability by enhancing the action of hypertonic solutions on the small intestinal mucosa.
通过测量口服乳果糖经尿液排泄的比例，研究了静脉注射胆囊收缩素（CCK）对正常受试者和胆囊切除术后患者肠道通透性的影响。当以高渗溶液给予CCK时，正常受试者的乳果糖排泄量显著增加（5小时内乳果糖49.4毫克，给予CCK后升至114.3毫克，p<0.001）。当以等渗溶液给予正常受试者CCK时，以及当以高渗或等渗溶液给予胆囊切除术后患者CCK时，CCK均未能影响乳果糖排泄。因此，“CCK效应”与胆囊排空有关。有人提出，胆囊收缩后释放的结合胆汁酸可通过增强高渗溶液对小肠黏膜的作用来影响肠道通透性。
