摄入高渗溶液后人体肠道通透性增加。
Increase in human intestinal permeability following ingestion of hypertonic solutions.
作者信息
Laker M F, Menzies I S
出版信息
J Physiol. 1977 Mar;265(3):881-94. doi: 10.1113/jphysiol.1977.sp011750.
Abstract
- A simple oral loading technique involving the ingestion of solutions containing lactulose is described. Timed urinary excretion of lactulose, which is non-metabolizable, is used as an indicator of intestinal permeability, and measured by quantitative paper chromatography. 2. This technique has been used to investigate the intestinal permeability of apparently healthy adults following the ingestion of solutions made hypertonic by the addition of the solutes sucrose, glucose, mannitol, glycerol, urea and sodium chloride. 3. These experiments show that intestinal permeability to lactulose increases as the solute concentration in the ingested solution is increased. Susceptibility to this effect, though consistent for each individual, shows considerable variation between subjects. 4. Factors thought to be pernitent to the enhancement of intestinal permeability by hypertonic solutions, and some possible implications of this, are discussed.
摘要
- 描述了一种简单的口服负荷技术，即摄入含有乳果糖的溶液。不可代谢的乳果糖的定时尿排泄用作肠道通透性的指标，并通过定量纸色谱法进行测量。2. 该技术已用于研究明显健康的成年人在摄入通过添加蔗糖、葡萄糖、甘露醇、甘油、尿素和氯化钠等溶质而变得高渗的溶液后的肠道通透性。3. 这些实验表明，随着摄入溶液中溶质浓度的增加，肠道对乳果糖的通透性增加。尽管对每个个体而言这种效应是一致的，但不同受试者之间存在相当大的差异。4. 讨论了被认为与高渗溶液增强肠道通透性相关的因素以及由此产生的一些可能影响。
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