Savchuk V I, Vinogradov A V, Pozin V M, Zhuravleva I A, Tumarkina K M
Kardiologiia. 1980 Jan;20(1):58-60.
On a model of reversible coronary blood flow disturbances in dogs short-term myocardial ischemia (2 to 15 min) in 16 chronic experiments caused an increase in the activity of total blood CPK by 57.3 +/- +/- 11.7 mE/ml (p less than 0.001) and of MB fraction by 6.9 +/- 1.23 mE/ml (p less than 0.001). Experiments in which the disturbances in coronary blood flow were repeated at intervals of 2-3 days showed that the changes in the activity of the enzymes occurred in definite stages. The results obtained on this model present new possibilities for elaborating diagnostic criteria of microfocal myocardial lesions.
在犬可逆性冠状动脉血流紊乱模型上，16项慢性实验中的短期心肌缺血（2至15分钟）使全血CPK活性增加57.3±11.7mE/ml（p＜0.001），MB组分活性增加6.9±1.23mE/ml（p＜0.001）。每隔2 - 3天重复冠状动脉血流紊乱的实验表明，酶活性变化呈特定阶段出现。在此模型上获得的结果为制定微灶性心肌病变的诊断标准提供了新的可能性。
