Konings A W, Smit Sibinga C T, Lamberts H B
Strahlentherapie. 1980 Feb;156(2):134-8.
Ionizing irradiation produced atheromas in the carotid arteries of hypercholesteremic rabbits which received a 0.5% cholesterol diet during 6 weeks. During this relatively short feeding period no atheromas were formed in the nonirradiated carotid arteries. When the animals received this diet for 5 months or a 2% cholesterol diet for 3 months also diet-induced atheromatosis could be found in the latter blood-vessels. A comparison was made between the lipid composition of the diet-induced and the radiation-induced fatty plaques. In all types of plaques the neutral lipids formed about 75 percent of the total lipids, esterified cholesterol being formed the main part of it followed by free cholesterol, phosphatidylcholine and sphingomyelin. A great similarity exists between the lipid composition of the diet-induced fatty plaques of the carotid artery, the aorta and the radiation-induced fatty plaque. It is concluded that radiation is one of the initiating factors in the atheromatous process of the large blood-vessels, leading to lipid infiltration because of injury to the endothelium.
电离辐射在高胆固醇血症家兔的颈动脉中产生了动脉粥样斑块，这些家兔在6周内接受了0.5%胆固醇饮食。在这个相对较短的喂养期内，未照射的颈动脉中未形成动脉粥样斑块。当动物接受这种饮食5个月或2%胆固醇饮食3个月时，在后者的血管中也可发现饮食诱导的动脉粥样硬化。对饮食诱导和辐射诱导的脂肪斑块的脂质组成进行了比较。在所有类型的斑块中，中性脂质约占总脂质的75%，其中酯化胆固醇占主要部分，其次是游离胆固醇、磷脂酰胆碱和鞘磷脂。颈动脉、主动脉的饮食诱导脂肪斑块与辐射诱导脂肪斑块的脂质组成之间存在很大相似性。结论是，辐射是大血管动脉粥样硬化过程中的起始因素之一，由于内皮损伤导致脂质浸润。
