Friedman R J, Moore S, Singal D P, Gent M
Arch Pathol Lab Med. 1976 Apr;100(4):189-95.
For four consecutive weeks, 61 rabbits received weekly injections of lymphocytotoxic-positive human serum into the left carotid artery and of autologous serum into the right carotid artery as a control. Serum cholesterol and serum triglyceride levels were measured before the study, in the second and fourth weeks of the study, and weekly thereafter. The results show that repeated intimal injury caused raised, lipid-containing thromboatherosclerotic lesions and that there was a consistent regression to lipid-free fibromusculoelastic plaques from the first week after completion of the injection regimen to the fourth week. Apparently, regeneration of an intact covering cell layer resulted in the elimination of lipid deposits from raised lesions, resulting in lipid-free fibromusculoelastic plaques. In addition, fatty streaks were observed to occur during regression. A statistically significant rise in serum cholesterol level during the phase of progression of lesions and a subsequent fall during regression were observed.
连续四周，61只兔子每周经左颈动脉注射淋巴细胞毒性阳性人血清，并经右颈动脉注射自体血清作为对照。在研究开始前、研究的第二周和第四周以及此后每周测量血清胆固醇和血清甘油三酯水平。结果表明，反复内膜损伤导致含脂质的血栓性动脉粥样硬化病变增加，并且从注射方案完成后的第一周到第四周，病变持续消退为无脂质的纤维肌弹性斑块。显然，完整覆盖细胞层的再生导致隆起病变中的脂质沉积消除，从而形成无脂质的纤维肌弹性斑块。此外，在消退过程中观察到出现了脂肪条纹。在病变进展阶段观察到血清胆固醇水平有统计学意义的升高，而在消退阶段随后下降。
