Masse D, Roux J F, Harlow A, Shapiro M
Am J Obstet Gynecol. 1980 Feb 15;136(4):505-8. doi: 10.1016/0002-9378(80)90679-1.
Fetuses from term and postmature rabbits were obtained and their livers incubated with palmitate-1-14C in room air. The net incorporation of the fatty acids into ketone bodies, lipids, and Co2 was measured at fixed and variable concentrations of cold glucose. Data from postmature liver show that lipid synthesis is decreased, 14CO2 production is increased, and ketone body formation is unchanged when compared with data from the term liver. The addition of cold glucose to a constant concentration of palmitate-1-14C causes a slight increase in lipid synthesis in thepostmature liver, in contrast to a decrease in the term liver. The experimental results indicate that liver lipid synthesis and glucose utilization are diminished in the postmature preparation. This suggests that the postmature fetal liver responds to the decreased availability of free fatty acid from the placenta and to the increasing hypoxia by metabolic adaptations resembling those observed during fasting and tissue hypoxia. These changes are somewhat similar to those observed in the neonate before the onset of breast-feeding. Fetal metabolism is, therefore, responsive to changes in placental transfer of fatty acids and to postmaturity.
获取足月和过熟兔的胎儿，并将其肝脏在室内空气中与1-14C棕榈酸一起孵育。在冷葡萄糖的固定和可变浓度下，测量脂肪酸向酮体、脂质和二氧化碳中的净掺入量。与足月肝脏的数据相比，过熟肝脏的数据显示脂质合成减少，14CO2生成增加，酮体形成未改变。向恒定浓度的1-14C棕榈酸中添加冷葡萄糖会使过熟肝脏中的脂质合成略有增加，这与足月肝脏中的减少形成对比。实验结果表明，过熟制剂中肝脏脂质合成和葡萄糖利用减少。这表明，过熟胎儿肝脏通过类似于在禁食和组织缺氧期间观察到的代谢适应，对来自胎盘的游离脂肪酸可用性降低和缺氧增加做出反应。这些变化与母乳喂养开始前新生儿中观察到的变化有些相似。因此，胎儿代谢对脂肪酸胎盘转运的变化和过熟有反应。
