Rossier M C, Truttmann A C, von Vigier R O, Stoffel P B, Bianchetti M G
Inselspital, University of Bern, Switzerland.
Magnes Res. 1999 Sep;12(3):175-9.
It has been postulated that parathormone, calcitonine, insulin and catecholamines are involved in extracellular magnesium homeostasis. Yet, there is still a rudimentary knowledge of the endocrine factors that control circulating magnesium homeostasis. The effects of exogenous glucagon injection on circulating total and ionized magnesium were investigated in 11 healthy humans (five females and six males, aged between 21 and 30, median 26 years). As compared with a control study, intravenous injection of a bolus of 1 mg of glucagon was associated with the expected raised glucose (at 5, 10, 20 and 30 min) and with decreased potassium (at 20 and 30 min) and inorganic phosphate (at 20 and 30 min) levels. Intravenous glucagon was not followed by significant changes in plasma total and ionized magnesium. Consequently, there is still little evidence for a glucagon-dependent control of the extracellular magnesium concentration after acute administration of glucagon.
据推测，甲状旁腺激素、降钙素、胰岛素和儿茶酚胺参与细胞外镁的稳态。然而，对于控制循环镁稳态的内分泌因素仍知之甚少。我们对11名健康人（5名女性和6名男性，年龄在21至30岁之间，中位数为26岁）进行了研究，观察外源性注射胰高血糖素对循环中总镁和离子化镁的影响。与对照研究相比，静脉注射1毫克胰高血糖素推注剂量后，血糖出现预期升高（在5、10、20和30分钟时），钾（在20和30分钟时）和无机磷酸盐（在20和30分钟时）水平降低。静脉注射胰高血糖素后，血浆总镁和离子化镁没有显著变化。因此，急性给予胰高血糖素后，几乎没有证据表明存在依赖胰高血糖素的细胞外镁浓度控制机制。
