Kokoschka E M, Spona J, Knobler R
Br J Dermatol. 1982 Nov;107 Suppl 23:54-9. doi: 10.1111/j.1365-2133.1982.tb01032.x.
Melanomas, as well as benign pigmented nevi, long-term cell cultures of melanoma cells and sixty-six normal skin biopsies, were evaluated for oestrogen and androgen receptor activity by a dextran-coated charcoal method. Oestrogen-binding was observed in 16% and androgen-binding in 40% of all investigated tumours. Normal skin showed 4% oestrogen and 41% androgen receptor activity; melanoma cell cultures expressed the same sex steroid hormone binding as tumour material. The quantitative receptor expression was found to be significantly higher in female than in male melanoma patients. Even though the study shows that to a certain extent malignant melanoma is a hormone dependent tumour, it seems that sex steroid hormones are not exclusively related to the biological behaviour of this tumour. In future, investigations should be expanded to other hormonal influences.
采用葡聚糖包被活性炭法，对黑色素瘤、良性色素痣、黑色素瘤细胞长期细胞培养物以及66份正常皮肤活检标本进行了雌激素和雄激素受体活性评估。在所有研究的肿瘤中，16%观察到雌激素结合，40%观察到雄激素结合。正常皮肤显示4%的雌激素和41%的雄激素受体活性；黑色素瘤细胞培养物表达的性类固醇激素结合情况与肿瘤组织相同。发现女性黑色素瘤患者的定量受体表达明显高于男性。尽管该研究表明恶性黑色素瘤在一定程度上是一种激素依赖性肿瘤，但性类固醇激素似乎并非唯一与该肿瘤的生物学行为相关。未来，研究应扩展到其他激素影响方面。
