Department of Clinical Pharmacy, College of Pharmacy, University of Kerbala, Kerbala, Iraq.
Department of Pharmacology and Toxicology, College of Pharmacy, University of Kerbala, Kerbala, Iraq.
Arch Razi Inst. 2022 Dec 31;77(6):2081-2087. doi: 10.22092/ARI.2022.358130.2156. eCollection 2022 Dec.
Carbimazole is a widespread drug utilized for treating hyperthyroidism. However, carbimazole usage could be associated with adverse effects such as liver damage and nephritis in rats. At the same time, turmeric, as a medical plant, has many antioxidant effects against liver and kidney toxicity. This study aimed to explore the protective effect of turmeric against carbimazole-induced toxicity in rats. The experiment was carried out on 24 male Wistar rats. They were separated into four groups, each with six animals, as follows: 1. Control group: represents a healthy animal, and each rat is only given standard food and distilled water for 30 days. 2. Carbimazole group: drenched orally 0.5 mg carbimazole daily for 30 days. 3. Turmeric group: drenched orally 100 mg turmeric powder daily for 30 days. 4. Carbimazole and turmeric group: drenched orally carbimazole 0.5 mg and turmeric 100 mg daily for 30 days. The study demonstrated a significant effect of turmeric powder in reducing the toxicity of carbimazole in both the kidney and liver biochemical parameters, in addition to the evidence of histological sections. Turmeric powder has the ability to reduce and prevent renal and hepatic toxicity induced by carbimazole overdose, which gives turmeric medical value.
卡比马唑是一种广泛用于治疗甲状腺功能亢进的药物。然而，卡比马唑的使用可能会导致大鼠的肝损伤和肾炎等不良反应。同时，姜黄作为一种药用植物，具有许多抗氧化作用，可以对抗肝和肾毒性。本研究旨在探讨姜黄对卡比马唑诱导的大鼠毒性的保护作用。该实验在 24 只雄性 Wistar 大鼠上进行。将它们分为四组，每组 6 只动物，如下所示：
对照组：代表健康动物，每只大鼠仅给予标准食物和蒸馏水 30 天。
卡比马唑组：每天口服 0.5mg 卡比马唑 30 天。
姜黄组：每天口服 100mg 姜黄粉 30 天。
卡比马唑和姜黄组：每天口服 0.5mg 卡比马唑和 100mg 姜黄粉 30 天。
研究表明，姜黄粉在降低肾和肝功能生化参数方面对卡比马唑的毒性有显著影响，此外还有组织学切片的证据。姜黄粉具有减轻和预防卡比马唑过量引起的肾和肝毒性的能力，这赋予了姜黄药用价值。
