Higenbottam T, Hamilton D, Feyerband C, Clark T J
Br J Dis Chest. 1980 Jan;74(1):37-46.
The acute airway response to smoking a single cigarette was assessed in eight symptom-free male smokers. The changes in airway function were determined using a computer analysis of maximal and partial expiratory flow volume curves together with measurement of airway resistance. The amount of smoke inhaled was assessed by measuring levels of nicotine in venous blood. When the results of all studies were analysed for the group as a whole only small and inconsistent changes in airway function were observed after smoking a cigarette, although all the subjects appeared to inhale the smoke. Although the group showed inconsistent changes, one subject exhibited a change on all four occasions in the studies using the maximal and partial expiratory flow volume curves. This was seen particularly for Vmax50 and Vmax40 obtained from the maximal and partial expiratory flow volume curves respectively. There appeared to be no difference between the two manoeuvres in their sensitivity to smoke-induced change. One subject showed a response to smoking when airways resistance was measured but this was on only one of two occasions. It is therefore possible that certain smokers are more susceptible to inhaled cigarette smoke and such individuals may be those who develop chronic airflow obstruction. The absence of a group effect was attributed to any smoking response being smaller than the other factors which affect measurements of airway function.
对8名无症状男性吸烟者吸入单支香烟后的急性气道反应进行了评估。气道功能的变化通过对最大呼气流量和部分呼气流量曲线进行计算机分析以及测量气道阻力来确定。吸入的烟雾量通过测量静脉血中尼古丁水平来评估。当对所有研究结果进行整体分析时，尽管所有受试者似乎都吸入了烟雾，但吸烟后仅观察到气道功能有微小且不一致的变化。尽管该组表现出不一致的变化，但在使用最大呼气流量和部分呼气流量曲线的研究中，有一名受试者在所有四次测试中均出现了变化。这在分别从最大呼气流量和部分呼气流量曲线获得的Vmax50和Vmax40中尤为明显。两种操作方法对烟雾诱导变化的敏感性似乎没有差异。有一名受试者在测量气道阻力时对吸烟有反应，但仅在两次测试中的一次出现这种情况。因此，某些吸烟者可能对吸入的香烟烟雾更敏感，而这类个体可能就是那些会发展为慢性气流阻塞的人。未观察到组效应是由于任何吸烟反应都小于影响气道功能测量的其他因素。
