Mayrhofer G
Blood. 1980 Mar;55(3):532-5.
Intraepithelial lymphocytes have been examined histochemically in the small intestines of normal rats and mice and in thymus-deficient animals (B rats and nude mice). It is concluded that these cells are heterogeneous, consisting of at least two subpopulations. One population contains granules, is thymus-independent, and is probably bone-marrow-derived. The other population does not contain granules and appears to be thymus-dependent. It is suggested that the granular cell, which may be a precursor of mucosal mast cells, is more properly a previously unrecognized nonlymphoid leukocyte of bone marrow origin.
已采用组织化学方法对正常大鼠和小鼠以及胸腺缺陷动物（B大鼠和裸鼠）小肠中的上皮内淋巴细胞进行了检测。得出的结论是，这些细胞具有异质性，至少由两个亚群组成。一个亚群含有颗粒，不依赖胸腺，可能来源于骨髓。另一个亚群不含颗粒，似乎依赖胸腺。有人提出，颗粒细胞可能是黏膜肥大细胞的前体，更确切地说是一种以前未被认识的源自骨髓的非淋巴细胞。
