Shaw D B, Holman R R, Gowers J I
Br Med J. 1980 Jan 19;280(6208):139-41. doi: 10.1136/bmj.280.6208.139.
A total of 381 patients with established (156) or potential (225) sinoatrial dysfunction were included in a 10-year prospective survey to determine the course of the disease and the benefits of pacing. With the exclusion of nine patients who were lost to follow-up, 61 were fitted with pacemakers. The overall survival of patients with established and potential dysfunction was similar and apparently indistinguishable from that of the normal population. Pacemaker implantation had little discernible effect on mortality though it reduced some incapacitating symptoms. These findings suggest that sinoatrial dysfunction is a relatively benign condition. Hence pacing should probably not be adopted as a routing measure but be reserved for patients with troublesome symptoms.
共有381例确诊(156例)或疑似(225例)窦房结功能障碍患者纳入了一项为期10年的前瞻性研究,以确定该疾病的病程及起搏治疗的益处。排除9例失访患者后,61例患者植入了起搏器。确诊和疑似功能障碍患者的总体生存率相似,且与正常人群明显无异。起搏器植入对死亡率几乎没有明显影响,但减轻了一些失能症状。这些发现表明,窦房结功能障碍是一种相对良性的疾病。因此,起搏治疗可能不应作为常规措施采用,而应保留给有严重症状的患者。