通过使用14C-氨基比林呼气试验预测对乙酰氨基酚中毒的结果。
Predicting outcome of paracetamol poisoning by use 14C-aminopyrine breath test.
作者信息
Saunders J B, Wright N, Lewis K O
出版信息
Br Med J. 1980 Feb 2;280(6210):279-80. doi: 10.1136/bmj.280.6210.279.
Abstract
The 14C-aminopyrine (14C-amidopyrine) breath test, carried out within 24-36 hours of an overdosage of paracetamol, was used to predict the extent of liver damage in 30 seriously poisoned patients. Mean 14CO2 excretion was 4.4% in 20 healthy control subjects; 5.5% in six patients who escaped injury; and 2.9%, 1.5%, and 0.2% in those with mild to moderate (12 patients), severe (eight patients), and fatal (four patients) liver damage respectively. This test proved to be a more reliable predictor of the extent of liver damage than plasma paracetamol concentration or half life or the results of conventional liver function tests and may enable treatment of hepatic failure to be started at an early stage.
摘要
在对乙酰氨基酚过量服用后的24至36小时内进行的14C-氨基比林呼气试验，用于预测30例严重中毒患者的肝损伤程度。20名健康对照者的平均14CO2排泄率为4.4%；6名未受伤患者为5.5%；轻度至中度肝损伤（12例）、重度肝损伤（8例）和致命性肝损伤（4例）患者的排泄率分别为2.9%、1.5%和0.2%。该试验被证明是比血浆对乙酰氨基酚浓度、半衰期或传统肝功能试验结果更可靠的肝损伤程度预测指标，并且可能使肝衰竭的治疗能够早期开始。
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