Yamanaka T, Ido K, Kimura K, Saito T
Clin Chim Acta. 1980 Feb 14;101(1):45-55. doi: 10.1016/0009-8981(80)90054-6.
Concentrations of thyroid hormones and thyrotropin (TSH) were measured in sera of clinically euthyroid patients with various liver diseases and compared with normal controls. The mean serum concentration of 3,3',5'-triiodothyronine (reverse T3, rT3) was significantly increased in patients with decompensated liver cirrhosis (p less than 0.01). This increase seemed to be dependent upon the hepatic damage, although it was not significant in patients with acute hepatitis, chronic hepatitis and compensated liver cirrhosis. The mean serum concentration of 3,3',5-triiodothyronine (T3) was significantly decreased in patients with decompensated liver cirrhosis (p less than 0.05). However, in patients with acute hepatitis, chronic hepatitis and compensated liver cirrhosis, the mean concentration of T3 was above the normal. The mean value of rT3/T3 ratios in patients with acute hepatitis, chronic hepatitis and compensated liver cirrhosis were similar to that of normal controls, but in patients with decompensated liver cirrhosis, the mean value of rT3/T3 ratios was markedly higher than that of normal controls. The rT3/T3 ratios have little or no correlation with some standard liver function tests. These results suggest that marked alterations of peripheral conversion of thyroxine (T4) to rT3 or T3 may be found only in a state of decompensated liver cirrhosis among the various liver diseases.
对患有各种肝脏疾病且临床甲状腺功能正常的患者血清中的甲状腺激素和促甲状腺激素（TSH）进行了测量，并与正常对照组进行比较。在失代偿期肝硬化患者中，血清3,3',5'-三碘甲状腺原氨酸（反三碘甲状腺原氨酸，rT3）的平均浓度显著升高（p<0.01）。这种升高似乎取决于肝脏损伤，尽管在急性肝炎、慢性肝炎和代偿期肝硬化患者中并不显著。在失代偿期肝硬化患者中，血清3,3',5-三碘甲状腺原氨酸（T3）的平均浓度显著降低（p<0.05）。然而，在急性肝炎、慢性肝炎和代偿期肝硬化患者中，T3的平均浓度高于正常水平。急性肝炎、慢性肝炎和代偿期肝硬化患者的rT3/T3比值平均值与正常对照组相似，但在失代偿期肝硬化患者中，rT3/T3比值的平均值明显高于正常对照组。rT3/T3比值与一些标准肝功能试验几乎没有相关性。这些结果表明，在各种肝脏疾病中，只有在失代偿期肝硬化状态下才可能发现甲状腺素（T4）向rT3或T3外周转化的明显改变。
