The exact nature of lymphomatoid granulomatosis remains unclear. Whether it represents a viral infection, an autoimmune disorder (possibly induced by a virus), or primary malignant lymphoma, is still to be determined. The histopathology and clinical course allows classification of lymphomatoid granulomatosis as a distinct entity. Unfortunately, there is no consistently effective therapy for this condition and the usual course is rapidly downhill, though temporary remissions may be obtained. Since presentation of these patients with cutaneous lesions is not unusual, dermatologists must be alert to the possibility of an underlying systemic vasculitis in patients with atypical cutaneous ulceration, especially when no obvious cause is apparent.
淋巴瘤样肉芽肿的确切性质仍不清楚。它是代表病毒感染、自身免疫性疾病（可能由病毒诱发）还是原发性恶性淋巴瘤，仍有待确定。组织病理学和临床病程使淋巴瘤样肉芽肿可被归类为一种独特的疾病实体。不幸的是，针对这种病症没有始终有效的治疗方法，通常病情会迅速恶化，尽管可能会获得暂时缓解。由于这些患者出现皮肤病变并不罕见，皮肤科医生必须警惕非典型皮肤溃疡患者潜在的系统性血管炎的可能性，尤其是在没有明显病因的情况下。
