Prerovský I, Romanovská L, Stríbrná J
Czech Med. 1980;3(1):36-42.
One of the causes of fixation of elevated blood pressure are structural changes in the arterial wall manifested at first by hypertrophy of the smooth muscle and later by proliferation of connective tissue. These changes can be evaluated in humans from the degree of vasodilatation during reactive hyperaemia. We found that the inability of adequate vasodilatation is typical for all types of hypertension, i.e. essential hypertension in young and elderly subjects stage I and II, and vasorenal hypertension. On the other hand, in patients with borderline hypertension structural changes do not develop. The inability of adequate vasodilatation in patients with hypertension persists also during a short-term reduction of the blood pressure to normal values as a result of therapy. In patients operated successfully on account of vasorenal hypertension the normal vasodilatation capacity is regained after one year of normalization of blood pressure.
血压升高难以恢复正常的原因之一是动脉壁的结构变化，起初表现为平滑肌肥大，随后是结缔组织增生。这些变化在人体中可通过反应性充血期间的血管舒张程度来评估。我们发现，无法充分血管舒张是所有类型高血压的典型特征，即青年和老年受试者I期和II期原发性高血压以及肾血管性高血压。另一方面，临界高血压患者不会出现结构变化。高血压患者即使在治疗使血压短期内降至正常水平后，仍存在无法充分血管舒张的情况。因肾血管性高血压而成功接受手术的患者，在血压恢复正常一年后，血管舒张能力恢复正常。
