Wannamaker B B, Morton W A, Gross A J, Saunders S
Epilepsia. 1980 Apr;21(2):155-62. doi: 10.1111/j.1528-1157.1980.tb04057.x.
Antiepileptic drug levels (AEDLs) may reflect how well patients adhere to prescribed medical regimens. Of 30 patients on stable drug regimens AEDLs were increased in 33% by decreasing clinic visit intervals from a mean of 3.4 months to 1.1 months. The testing situation was applied to patients who had AEDLs in the "therapeutic range" (n = 15) as well as those with one or more AEDLs below "therapeutic range" (n = 15). In the latter group 73% of patients showed improvement in AEDLs. Although a less reliable parameter, verbally reported seizure frequencies were also improved. Overall, the reduction in clinic visit interval could be expected to yield improvement in 46 to 80% (confidence interval = 95%). These patients responded equally well to physician and non-physician practitioners. This technique may be useful as an intervening measure for those patients who are noncompliant.
抗癫痫药物水平（AEDLs）可能反映患者对规定医疗方案的依从程度。在30名采用稳定药物方案的患者中，通过将门诊就诊间隔从平均3.4个月缩短至1.1个月，33%的患者AEDLs升高。测试情况适用于AEDLs处于“治疗范围”的患者（n = 15）以及AEDLs有一项或多项低于“治疗范围”的患者（n = 15）。在后一组中，73%的患者AEDLs有所改善。尽管口头报告的癫痫发作频率是一个不太可靠的参数，但也有所改善。总体而言，预计门诊就诊间隔的缩短可使46%至80%的患者病情改善（置信区间 = 95%）。这些患者对医生和非医生从业者的反应同样良好。对于那些不依从的患者，这种技术可能作为一种干预措施有用。
