Bolli G, Compagnucci P, Cartechini M G, Santeusanio F, Cirotto C, Scionti L, Brunetti P
Diabetes. 1980 Apr;29(4):272-7. doi: 10.2337/diab.29.4.272.
HbA1(a+b+c)(HbA1) was determined chromatographically in 107 subjects with normal fasting plasma glucose (FPG) and 112 patients with overt diabetes. Subjects with normal FPG were divided into two groups based on their response to two oral glucose tolerance tests (OGTTs), at an interval of 2 mo. In 40 subjects with normal OGTT (group I), HbA1 ranged from 5.2% to 7.2%, while in 67 subjects with abnormal OGTT (group II), it ranged from 6.3% to 9.6%. HbA1 levels were significantly higher in group II than in group I (7.7 +/- 0.09% versus 6.4 +/- 0.08%, mean +/- SEM, P less than 0.0005), but 14 subjects of group II had HbA1 levels less than 7.2%. No correlation was found between HbA1 and FPG, OGTT peak, and curve area in either group. However, the correlation became significant in all 107 subjects with normal FPG (groups I + II). In patients with overt diabetes, HbA1 ranged from 6.3% to 18% (11.9 +/- 0.22%) and correlated with FPG (r = 0.78, P less than 0.0005). The traditional OGTT seems more sensitive than the HbA1 measurement in detecting subjects with reduced carbohydrate tolerance. HbA1 level, on the other hand, is known to be more specific indicator of structural abnormalities following long-term hyperglycemia. Thus HbA1 determination might be a helpful test along with OGTT to improve both selection and follow-up subjects with true borderline diabetes.
采用色谱法测定了107例空腹血糖（FPG）正常的受试者和112例显性糖尿病患者的糖化血红蛋白A1（a+b+c）[糖化血红蛋白（HbA1）]。FPG正常的受试者根据其对两次口服葡萄糖耐量试验（OGTT）（间隔2个月）的反应分为两组。在40例OGTT正常的受试者（I组）中，HbA1范围为5.2%至7.2%，而在67例OGTT异常的受试者（II组）中，其范围为6.3%至9.6%。II组的HbA1水平显著高于I组（分别为7.7±0.09%和6.4±0.08%，均值±标准误，P<0.0005），但II组中有14例受试者的HbA1水平低于7.2%。在两组中，均未发现HbA1与FPG、OGTT峰值及曲线面积之间存在相关性。然而，在所有107例FPG正常的受试者（I组+II组）中，这种相关性变得显著。在显性糖尿病患者中，HbA1范围为6.3%至18%（11.9±0.22%），且与FPG相关（r=0.78，P<0.0005）。传统的OGTT在检测糖耐量降低的受试者方面似乎比HbA1测量更敏感。另一方面，已知HbA1水平是长期高血糖后结构异常的更特异指标。因此，测定HbA1可能是一项有用的检查，可与OGTT一起用于改善对真正临界糖尿病患者的筛选和随访。
