巯基激活细胞溶素与胆固醇的结合
Binding of cholesterol by sulfhydryl-activated cytolysins.
作者信息
Johnson M K, Geoffroy C, Alouf J E
出版信息
Infect Immun. 1980 Jan;27(1):97-101. doi: 10.1128/iai.27.1.97-101.1980.
Abstract
The binding of cholesterol by pneumolysin, alveolysin, and streptolysin O has been demonstrated. The properties of the cytolysin-cholesterol interaction parallel those of cytolysin-erythrocyte interaction in that the reaction is rapid, temperature independent, decreased at elevated pH, and shows the same specificity with respect to other related sterols. However, oxidized or p-hydroxymercuribenzoate-treated thoxin showed no decrease in cholesterol-binding activity, whereas the ability of cytolysin to bind to erythrocytes was modified by such treatment.
摘要
已经证实肺炎溶血素、肺泡溶血素和链球菌溶血素O与胆固醇的结合。溶细胞素与胆固醇的相互作用特性与溶细胞素与红细胞的相互作用特性相似，即反应迅速、与温度无关、在pH升高时降低，并且对其他相关固醇显示出相同的特异性。然而，经氧化或对羟基汞苯甲酸处理的毒素的胆固醇结合活性没有降低，而溶细胞素与红细胞结合的能力则因这种处理而改变。
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