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2
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3
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9
Binding of cholesterol by sulfhydryl-activated cytolysins.巯基激活细胞溶素与胆固醇的结合
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10
Effects of pneumolysin on human polymorphonuclear leukocytes and platelets.肺炎溶血素对人多形核白细胞和血小板的影响。
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Neurospora diphosphopyridine nucleotidase.粗糙脉孢菌二磷酸吡啶核苷酸酶
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A streptococcal enzyme that acts specifically upon diphosphopyridine nucleotide: characterization of the enzyme and its separation from streptolysin O.一种对二磷酸吡啶核苷酸具有特异性作用的链球菌酶：该酶的特性及其与链球菌溶血素O的分离
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[Action of streptolysin O on cellular membranes. II.--Kinetics of erythrocyte lysis].[链球菌溶血素O对细胞膜的作用。II.——红细胞溶解的动力学]
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Characteristics of streptolysin O action.链球菌溶血素O的作用特性。
Infect Immun. 1971 Dec;4(6):683-7. doi: 10.1128/iai.4.6.683-687.1971.
6
Purification of pneumolysin.肺炎溶血素的纯化
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Identity of streptolysin-O and NAD-glycohydrolase (EC 3.2.2.5).链球菌溶血素-O与NAD-糖水解酶（EC 3.2.2.5）的同一性。
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[Purification and crystallization of NAD glycohydrolase of C streptococci].[C群链球菌NAD糖水解酶的纯化与结晶]
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纯化肺炎球菌溶血素的特性

Properties of purified pneumococcal hemolysin.

作者信息

Johnson M K

出版信息

Infect Immun. 1972 Nov;6(5):755-60. doi: 10.1128/iai.6.5.755-760.1972.

DOI:10.1128/iai.6.5.755-760.1972
PMID:4404668
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422606/
Abstract

With a purified preparation of pneumococcal hemolysin, a sigmoid relationship was found to exist between lysin concentration and hemolytic activity. Hemolysis was inhibited by a high ratio of erythrocytes to lysin, suggesting a multi-hit mechanism of action. Reaction rate decreased rapidly with time, possibly due to competition between ghosts and unlysed erythrocytes for fixation of lysin. The effects of pH and various agents on the processes of lysin adsorption and hemoglobin release were determined. The pneumococcal preparation did not possess nicotinamide adenine dinucleotide glycohydrolase activity.

摘要

使用纯化的肺炎球菌溶血素制剂，发现溶素浓度与溶血活性之间存在S形关系。高比例的红细胞与溶素可抑制溶血，提示存在多重打击作用机制。反应速率随时间迅速降低，这可能是由于空壳红细胞与未裂解红细胞竞争溶素固定所致。测定了pH值和各种试剂对溶素吸附和血红蛋白释放过程的影响。肺炎球菌制剂不具有烟酰胺腺嘌呤二核苷酸糖水解酶活性。