Khanna N N, Bada H S, Somani S M
J Pediatr. 1980 Mar;96(3 Pt 1):494-9. doi: 10.1016/s0022-3476(80)80708-6.
Simultaneous blood and saliva samples were drawn for determination of caffeine and theophylline concentrations in 17 infants receiving caffeine or theophylline therapy for apnea of prematurity. The relationship between serum and saliva concentrations in each drug treatment group was explored using (1) regression analysis and (2) serum:saliva ratio. Significant correlations were observed between serum and salivary concentrations. Salivary concentrations approximated 76 to 80% of the serum concentrations based on the derived serum:saliva ratios. When salivary concentrations were less than 8 microgram/ml, the serum concentrations did not exceed therapeutic range and no clinical toxicity was noted. Monitoring of salivary drug concentrations as an alternative to serum drug concentrations may be useful in preterm infants on methylxanthine therapy. When salivary concentrations exceed 8 microgram/ml, serum concentrations should be determined.
采集了17名接受咖啡因或茶碱治疗早产儿呼吸暂停的婴儿的血液和唾液样本，以测定咖啡因和茶碱浓度。使用（1）回归分析和（2）血清：唾液比值探讨了每个药物治疗组中血清和唾液浓度之间的关系。观察到血清和唾液浓度之间存在显著相关性。根据得出的血清：唾液比值，唾液浓度约为血清浓度的76%至80%。当唾液浓度低于8微克/毫升时，血清浓度未超过治疗范围，未观察到临床毒性。监测唾液药物浓度作为血清药物浓度的替代方法，可能对接受甲基黄嘌呤治疗的早产儿有用。当唾液浓度超过8微克/毫升时，应测定血清浓度。
