Eaton G J, Johnson F N, Custer R P, Crane A R
Lab Anim. 1980 Jan;14(1):17-24. doi: 10.1258/002367780780943141.
This stock of albino mice is minimally inbred (0.5% per generation), and has been rigidly selected for fecundity. It is widely employed in oncological and pharmaceutical research. Spontaneous tumours arose in 55% of animals, multiple in 28%, averaging 1.66 per mouse. Females developed tumours at an earlier age than males. Predominant tumour types were pulmonary (23.1%), lymphoreticular (20%), and mammary (14%--23% of females). Miscellaneous tumour types (42.9%) ranged in frequency from 0.2 to 2.0%, the latter being hepatomas. Distribution of mammary tumours indicated that milk-borne mammary tumour virus was absent. Non-neoplastic disease was present in 58.6%, 24.1% being pulmonary and predominant in the young, while renal (31.2%) and cardiovascular (10.2%) disease was common in the elderly. Males outlived females.
这种白化小鼠品系近亲繁殖程度最低（每代0.5%），并且经过严格的繁殖力筛选。它广泛应用于肿瘤学和药物研究。55%的动物出现自发性肿瘤，28%为多发性肿瘤，每只小鼠平均1.66个。雌性比雄性更早发生肿瘤。主要肿瘤类型为肺部肿瘤（23.1%）、淋巴网状组织肿瘤（20%）和乳腺肿瘤（占雌性的14% - 23%）。其他肿瘤类型（42.9%）的发生率在0.2%至2.0%之间，后者为肝癌。乳腺肿瘤的分布表明不存在经乳汁传播的乳腺肿瘤病毒。58.6%存在非肿瘤性疾病，其中24.1%为肺部疾病，在年轻动物中占主导，而肾脏疾病（31.2%）和心血管疾病（10.2%）在老年动物中较为常见。雄性比雌性寿命长。
