Stemmann E A, Wolff G E
Monatsschr Kinderheilkd (1902). 1980 Feb;128(2):89-92.
In 10 children with asthma bronchiale aged 4 10/12--14 3/12 years, Salbutamol was given rectally and by pressurized aerosol. After 1 h plasma concentration of free salbutamol and lung function were measured. Plasma concentrations of free salbutamol ranged between 1.2--12.3 ng/ml, when 2 mg of salbutamol were given rectally and between less than 0.5--1.6 ng/ml, when a dose of 0.2 mg salbutamol was inhaled. Airway resistance decreased significantly after both forms of treatment but there was no statistical difference. Plasma concentrations of free salbutamol were rather low following an aerosol dose of 0.2 mg salbutamol, suggesting a topical action of salbutamol. When taken rectally improvement in lung function seemed to be related to plasma levels of free salbutamol.
对10名年龄在4岁10个月至14岁3个月的支气管哮喘患儿，分别采用直肠给药和压力定量气雾剂给药的方式给予沙丁胺醇。1小时后，测定游离沙丁胺醇的血浆浓度和肺功能。直肠给予2mg沙丁胺醇后，游离沙丁胺醇的血浆浓度范围为1.2 - 12.3ng/ml；吸入0.2mg沙丁胺醇后，游离沙丁胺醇的血浆浓度范围低于0.5 - 1.6ng/ml。两种给药方式后气道阻力均显著下降，但无统计学差异。吸入0.2mg沙丁胺醇后，游离沙丁胺醇的血浆浓度相当低，提示沙丁胺醇具有局部作用。直肠给药时，肺功能的改善似乎与游离沙丁胺醇的血浆水平有关。
