Himmelberger D U, Brown B W, cohen E N
Am J Epidemiol. 1978 Dec;108(6):470-9. doi: 10.1093/oxfordjournals.aje.a112645.
A multiple logistic regression analysis of 12,914 pregnancies and 10,523 live births, based on a mail survey of professional women in medicine, was carried out to determine the relationship between maternal cigarette smoking, and spontaneous abortion and congenital abnormality. After controlling for interfering variables (age, exposure to trace anesthetic gases, pregnancy history, and mailing response), a statistically significant increase in risk associated with maternal cigarette smoking was found for spontaneous abortions and congenital abnormalities. The risk of spontaneous abortion for the heavy smoker is estimated to be as much as 1.7 times that of the nonsmoker in certain risk groups. The risk for congenital abnormality for babies born of smoking mothers is estimated to be as much as 2.3 times that of the nonsmoker, depending on age, pregnancy history, and other factors.
基于对医学领域职业女性的邮件调查，对12914例妊娠和10523例活产进行了多元逻辑回归分析，以确定孕妇吸烟与自然流产和先天性异常之间的关系。在控制了干扰变量（年龄、微量麻醉气体暴露、妊娠史和邮件回复情况）后，发现孕妇吸烟与自然流产和先天性异常的风险存在统计学上的显著增加。在某些风险组中，重度吸烟者的自然流产风险估计是非吸烟者的1.7倍之多。根据年龄、妊娠史和其他因素，吸烟母亲所生孩子的先天性异常风险估计是非吸烟者的2.3倍之多。
