Kline J, Levin B, Stein Z, Susser M, Warburton D
Environ Health Perspect. 1981 Dec;42:119-26. doi: 10.1289/ehp.8142119.
Evaluations of the health effects of exposures in the workplace and environment have broadened to include effects on reproduction, as well as on the development of cancer. Models to assess risks associated with varying doses of exposure rest almost entirely on data about cancer. In this paper we discuss some distinctive features of reproduction which bear on the interpretation of such models, when applied to reproduction, rather than carcinogenesis. Dose-response curves describe the relationship between two exposures (smoking and alcohol drinking) and two outcomes (spontaneous abortion and birthweight) are used to illustrate some of the questions which arise in attempting to determine a "safe" level of exposure.
对工作场所和环境中接触因素的健康影响评估已扩大到包括对生殖以及癌症发展的影响。评估与不同接触剂量相关风险的模型几乎完全基于癌症数据。在本文中，我们讨论了生殖的一些独特特征，这些特征在将此类模型应用于生殖而非致癌作用时，对模型的解释具有重要意义。剂量反应曲线描述了两种接触因素（吸烟和饮酒）与两种结果（自然流产和出生体重）之间的关系，用于说明在试图确定“安全”接触水平时出现的一些问题。
