Saurel-Cubizolles M J, Hays M, Estryn-Behar M
INSERM Unité 149, Villejuif, France.
Int Arch Occup Environ Health. 1994;66(4):235-41. doi: 10.1007/BF00454361.
The aim of this study was to analyse the relationship between work in an operating room and pregnancy outcome, as described by the rates of spontaneous abortion and of birth defects. The population comprised the female nurses of 17 hospitals in Paris, interviewed in 1987-1989. An exposed group included all operating room nurses, and a control group was composed of female nurses in other departments matched by hospital, age and duration of service. Each woman described all prior pregnancies. In total, 776 pregnancies were described by 418 nurses who were first pregnant in 1970 or thereafter; ectopic pregnancies, those terminated by voluntary induced abortion and those leading to multiple births were excluded. The rate of spontaneous abortion was significantly higher for pregnancies during which women worked in an operating room than for the other pregnancies. Birth defects were not significantly related to work in an operating room during pregnancy. These results are in agreement with others showing a significant relationship between occupational exposure to operating rooms and spontaneous abortion, although identification of the responsible factor remains difficult. They suggest that effective ventilating systems should be installed in all operating rooms and that special preventive measures must be taken for women of childbearing age.
本研究旨在分析手术室工作与妊娠结局之间的关系，以自然流产率和出生缺陷率来描述。研究对象为1987年至1989年接受访谈的巴黎17家医院的女护士。暴露组包括所有手术室护士，对照组由其他科室与医院、年龄和服务年限相匹配的女护士组成。每位女性描述了所有既往妊娠情况。共有418名1970年或之后首次怀孕的护士描述了776次妊娠；宫外孕、自愿人工流产终止的妊娠以及多胎妊娠被排除在外。女性在手术室工作期间的妊娠自然流产率显著高于其他妊娠。出生缺陷与孕期在手术室工作无显著关联。这些结果与其他研究一致，表明职业暴露于手术室与自然流产之间存在显著关系，尽管确定相关因素仍很困难。研究表明，所有手术室均应安装有效的通风系统，并且必须对育龄女性采取特殊的预防措施。
