原发性情感障碍病情缓解期患者胆碱能快速诱导快速眼动睡眠现象

Faster cholinergic REM sleep induction in euthymic patients with primary affective illness.

作者信息

Sitaram N, Nurnberger J I, Gershon E S, Gillin J C

出版信息

Science. 1980 Apr 11;208(4440):200-2. doi: 10.1126/science.7361118.

Abstract

Arecoline, a cholinergic muscarinic receptor agonist, induced rapid eye movement sleep significantly more rapidly in patients with primary affective illness in remission than in normal control subjects matched for age and sex. These results, and others, suggest that patients with primary affective illness may have a supersensitive cholinergic system both when they are ill and when their symptoms are in clinical remission.

摘要

槟榔碱，一种胆碱能毒蕈碱受体激动剂，在原发性情感性疾病缓解期患者中比在年龄和性别匹配的正常对照受试者中更迅速地诱导快速眼动睡眠。这些结果以及其他结果表明，原发性情感性疾病患者在患病时以及症状处于临床缓解期时可能都有一个超敏的胆碱能系统。