Abrams S M, Degnan T J, Vinciguerra V
Arch Intern Med. 1980 Apr;140(4):576-7.
Chloramphenicol-induced aplastic anemia is well described in the literature following oral use of the drug. Here we describe the first case we are aware of in which chloramphenicol eye ointment resulted in severe aplastic anemia and, subsequently, death. At least two cases of marrow hypoplasia following use of chloramphenicol eyedrops have been described previously in the literature. The absorption route, its possible relation to the pathogenesis of aplastic anemia, and the two types of marrow toxicity associated with chloramphenicol are reviewed. This case emphasizes the necessity for the same careful consideration for the use of topical preparations that one affords the use of parenterally and orally administered medications.
口服氯霉素后引发再生障碍性贫血在文献中有充分描述。在此，我们报告首例已知因使用氯霉素眼膏导致严重再生障碍性贫血并最终死亡的病例。此前文献中已描述过至少两例使用氯霉素滴眼液后出现骨髓发育不全的病例。本文对氯霉素的吸收途径、其与再生障碍性贫血发病机制的可能关系以及与氯霉素相关的两种骨髓毒性类型进行了综述。该病例强调，对于局部用药，如同对胃肠外和口服给药一样，必须予以同样谨慎的考虑。
