Morgan W J, Hutchison D, Johnson H M
Br J Surg. 1980 Feb;67(2):140-1. doi: 10.1002/bjs.1800670222.
In wounds of the hand and forearm treated within 4 h of injury, prophylactic clindamycin, in a dose of 150 mg 6-hourly for 5 days, did not reduce the infection rate. In wounds treated after 4 h the infection rate was reduced, but not significantly so. There was a significant reduction in the infection rate comparing all wounds treated within 4 h with those treated after 4 h. Early treatment of wounds is more important than prophylactic antibiotics, although these may have a part to play where late treatment is unavoidable.
对于伤后4小时内接受治疗的手部和前臂伤口，预防性使用克林霉素，剂量为150毫克，每6小时一次，连用5天，并未降低感染率。对于伤后4小时后接受治疗的伤口，感染率有所降低，但降幅并不显著。将所有伤后4小时内接受治疗的伤口与伤后4小时后接受治疗的伤口相比，感染率有显著降低。伤口的早期治疗比预防性使用抗生素更为重要，不过在无法避免延迟治疗的情况下，抗生素可能也能发挥一定作用。
