Burger A, Nicod P, Suter P, Vallotton M B, Vagenakis P, Braverman L
Lancet. 1976 Mar 27;1(7961):653-5. doi: 10.1016/s0140-6736(76)92774-4.
In acute and subacute disease the active thyroid hormones, triiodothyronine (T3) and tetraiodothyroacetic acid (tetrac), are decreased while serum-thyroxine (T4) levels tend to be slightly reduced. Conversely, the inactive metabolite, reverse triiodothyronine (reverse T3), is increased indicating a diversion of T4 metabolism from an activating to an inactivating pathway. With convalescence the serum levels of T3, tetrac, and T4 recover while reverse T3 decreases to normal. These changes occur without significant alterations in serum levels of thyroid-stimulating hormone, indicating maintenance of euthyroidism throughout disease.
在急性和亚急性疾病中，活性甲状腺激素三碘甲状腺原氨酸（T3）和四碘甲状腺乙酸（tetrac）减少，而血清甲状腺素（T4）水平往往略有降低。相反，无活性代谢物反三碘甲状腺原氨酸（反T3）增加，表明T4代谢从激活途径转向失活途径。随着病情康复，T3、tetrac和T4的血清水平恢复正常，而反T3降至正常。这些变化发生时，促甲状腺激素的血清水平无明显改变，表明在整个疾病过程中甲状腺功能正常得以维持。
