Bubis M J, Anthonisen N R
Am Rev Respir Dis. 1978 Nov;118(5):947-53. doi: 10.1164/arrd.1978.118.5.947.
A case of idiopathic alveolar hypoventilation is described. Although lung function was normal, the alveolar-arterial O2 tension difference was abnormally large for reasons which were unclear. Despite this, the patient's pulmonary hypertension and polycythemia were out of proportion to the relatively mild hypoxemia that he demonstrated while awake. Sleep was associated with severe hypoxemia, and administration of O2 during sleep produced CO2 retention. The patient did well on no treatment for 5 years, until respiratory infection precipitated severe hypoxemia and pulmonary hypertension. He was treated with O2, at first continuously then nocturnally (12 hours per day), with reversal of polycythemia and pulmonary hypertension. He was then treated with nocturnal O2 as an outpatient for 7 months and maintained his improvement. Nocturnal administration of O2 may be an effective treatment of some forms of primary hypoventilation.
本文描述了一例特发性肺泡低通气病例。尽管肺功能正常，但肺泡-动脉血氧分压差异常增大，原因不明。尽管如此，患者的肺动脉高压和红细胞增多症与他清醒时表现出的相对较轻的低氧血症不相称。睡眠与严重低氧血症相关，睡眠期间吸氧会导致二氧化碳潴留。该患者在未接受治疗的情况下状况良好达5年，直到呼吸道感染引发严重低氧血症和肺动脉高压。他接受了吸氧治疗，起初是持续吸氧，然后改为夜间吸氧（每天12小时），红细胞增多症和肺动脉高压得到缓解。随后，他作为门诊患者接受夜间吸氧治疗7个月，病情持续改善。夜间吸氧可能是治疗某些形式的原发性低通气的有效方法。
