Buselmeier T J
Cutis. 1980 Apr;25(4):397, 405.
Following the initial report by Farber and South on nonsurgical nail avulsion with urea ointment and their emphasis that the therapy was not helpful in treating nondystrophic nails, we utilized a similar therapy to treat a sixty-seven year old patient who had severe arteriosclerotic cardiovascular disease and relatively nondystrophic but symptomatic large toenail disease. Because their formulation was ineffective on nondystrophic nails, a formulation with an additive, 20 percent urea and 10 percent salicylic acid preparation was used. After a period of two weeks of occlusive paplication, painless nonsurgical avulsion was achieved. Moderate maceration of surrounding skin was temporary and relatively asymptomatic.
在法伯和索思首次报道使用尿素软膏进行非手术拔甲，并强调该疗法对治疗非营养不良性指甲无效后，我们采用了类似疗法治疗一名67岁患者，该患者患有严重的动脉硬化性心血管疾病，脚趾甲相对无营养不良但有症状。由于他们的配方对非营养不良性指甲无效，因此使用了添加20%尿素和10%水杨酸制剂的配方。经过两周的封闭敷用，实现了无痛非手术拔甲。周围皮肤的中度浸渍是暂时的，相对无症状。
