Sparks H V
Fed Proc. 1980 Apr;39(5):1487-90.
This article reviews work on the cause of the vasodilation associated with exercise in the absence of sufficient blood flow. This situation results in a prolonged period of vasodilation that far exceeds the time required for muscle oxygen consumption (VO2) to return to rest. This prolonged vasodilation is not caused by release of K+ or lactic acid, hyperosmolarity, or lowered vessel wall pO2. The early portion appears to be caused by adenosine release, because tissue adenosine is elevated and theophylline partly blocks the response. The remainder may be caused by prostaglandin release which is elevated late in the post-exercise vasodilation period. Indomethacin reduces the duration of the vasodilation. Histamine may play a role in the vasodilation because tripelennamine reduces it. The vasodilation during the exercise bout is probably the result of at least three factors. K+ release and hyperosmolarity probably help to initiate the vasodilation and adenosine probably becomes the dominant factor after the first 10--20 minutes.
本文综述了关于在血流量不足情况下运动相关血管舒张原因的研究。这种情况会导致血管舒张期延长，远远超过肌肉耗氧量（VO₂）恢复到静息状态所需的时间。这种延长的血管舒张并非由钾离子或乳酸释放、高渗性或血管壁氧分压降低引起。早期部分似乎是由腺苷释放引起的，因为组织腺苷升高，且茶碱可部分阻断这种反应。其余部分可能是由前列腺素释放引起的，前列腺素在运动后血管舒张期后期升高。吲哚美辛可缩短血管舒张的持续时间。组胺可能在血管舒张中起作用，因为曲吡那敏可减轻血管舒张。运动期间的血管舒张可能至少由三个因素导致。钾离子释放和高渗性可能有助于启动血管舒张，而腺苷可能在最初10 - 20分钟后成为主导因素。
