Lindblom B, Hamberger L, Ljung B
Fertil Steril. 1980 Mar;33(3):283-7. doi: 10.1016/s0015-0282(16)44595-4.
The isthmic portion of the human fallopian tube was excised during surgery and the ampullary-isthmic junction was identified. Muscle strips (1-mm wide) were dissected from the outer longitudinal and the inner circular layers at this region and used for isometric recordings of spontaneous contractile activity in organ bath experiments. It was found that the amplitude and the duration of individual contractions were similar during various phases of normal menstrual cycles, whereas the frequency of contractions was significantly increased during the periovulatory period in both circular and longitudinal muscle. During early pregnancy or treatment with combined oral contraceptives the motility pattern was similar to that observed in the late luteal phase, being characterized by a comparatively low contraction frequency. In the perimenopausal period, irregular patterns were frequently observed whereas preparations obtained from postmenopausal women exhibited a very weak activity with low amplitude and frequency of contractions. Similar activity was encountered in specimens from patients treated with androgens. It is concluded that endogenous estrogens stimulate human oviductal contractility while endogenous progesterone has a depressive action on tubal activity. Both effects occur with a certain delay and are prolonged for up to 3 days, i.e., the changes in the serum levels of ovarian steroids and the induced alterations of tubal contractility are out of phase.
在手术过程中切除人输卵管的峡部，并确定壶腹 - 峡部连接处。从该区域的外纵肌层和内环肌层切取宽1毫米的肌条，用于器官浴实验中自发收缩活动的等长记录。研究发现，在正常月经周期的各个阶段，单个收缩的幅度和持续时间相似，而在排卵前期，环肌和纵肌的收缩频率均显著增加。在妊娠早期或使用复方口服避孕药治疗期间，运动模式与黄体晚期观察到的相似，其特征是收缩频率相对较低。在围绝经期，经常观察到不规则模式，而绝经后妇女的标本表现出非常微弱的活动，收缩幅度和频率都很低。在接受雄激素治疗的患者标本中也观察到类似的活动。结论是内源性雌激素刺激人输卵管的收缩力，而内源性孕酮对输卵管活动有抑制作用。两种作用都有一定延迟，并持续长达3天，即卵巢甾体激素血清水平的变化与输卵管收缩力的诱导变化不同步。
