Bastos Natália Marins, Ferst Juliana Germano, Goulart Rodrigo Silva, Coelho da Silveira Juliano
Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Pirassununga, SP, Brasil.
Departamento de Zootecnia, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Pirassununga, SP, Brasil.
Anim Reprod. 2022 Apr 20;19(1):e20220015. doi: 10.1590/1984-3143-AR2022-0015. eCollection 2022.
The oviduct is an important reproductive structure that connects the ovary to the uterus and takes place to important events such as oocyte final maturation, fertilization and early embryonic development. Thus, gametes and embryo can be directly influenced by the oviductal microenvironment composed by epithelial cells such secretory and ciliated cells and oviductal fluid. The oviduct composition is anatomically dynamic and is under ovarian hormones control. The oviductal fluid provides protection, nourishment and transport to gametes and embryo and allows interaction to oviductal epithelial cells. All these functions together allows the oviduct to provides the ideal environment to the early reproductive events. Extracellular vesicles (EVs) are biological nanoparticles that mediates cell communication and are present at oviductal fluid and plays an important role in gametes/embryo - oviductal cells communication. This review will present the ability of the oviducts based on its dynamic and systemic changes during reproductive events, as well as the contribution of EVs in this process.
输卵管是一个重要的生殖结构，它连接卵巢和子宫，并参与卵母细胞最终成熟、受精和早期胚胎发育等重要事件。因此，配子和胚胎会直接受到由上皮细胞（如分泌细胞和纤毛细胞）以及输卵管液组成的输卵管微环境的影响。输卵管的组成在解剖学上是动态变化的，受卵巢激素的控制。输卵管液为配子和胚胎提供保护、营养和运输，并允许与输卵管上皮细胞相互作用。所有这些功能共同使输卵管为早期生殖事件提供理想的环境。细胞外囊泡（EVs）是介导细胞通讯的生物纳米颗粒，存在于输卵管液中，在配子/胚胎与输卵管细胞的通讯中起重要作用。本综述将介绍输卵管在生殖事件中基于其动态和系统性变化的能力，以及细胞外囊泡在这一过程中的作用。
