Srivastava U K, Malaviya B
Indian J Physiol Pharmacol. 1980 Jan-Mar;24(1):49-55.
Silastic implants containing crystalline Norethisterone Enanthate (NE) inserted into the epididymal fat-pads unilaterally were found to bring about a drastic reduction (P smaller than 0.01) in the size and weight of the testis six weeks after implant insertion on the side bearing the progestin implant. The ipsilateral (treated side) testis, caput and cauda epididymis and the vas deferens showed either a complete absence of spermatozoa or occasional few immotile and decapitated sperms. In contrast, the smears obtained from the contralateral testis and the corresponding epididymal segments and the vas showed a population of entirely normal and motile spermatozoa. There was apparently no effect on the epididymis as the ipsilateral epididymis was almost similar (weight-wise) to that of the contralateral side. The results suggested an apparently local effect of NE implants inserted into the epididymal fat pads. The feasibility of the approach for long-term fertility regulation in males is discussed.
将含有结晶庚酸炔诺酮（NE）的硅橡胶植入物单侧插入附睾脂肪垫后，发现在植入孕激素植入物一侧六周后，睾丸的大小和重量急剧减少（P小于0.01）。同侧（治疗侧）睾丸、附睾头和尾以及输精管要么完全没有精子，要么偶尔有少量不活动和断头的精子。相比之下，从对侧睾丸、相应的附睾段和输精管获得的涂片显示有大量完全正常且活动的精子。对附睾显然没有影响，因为同侧附睾（重量方面）与对侧几乎相似。结果表明，将NE植入物插入附睾脂肪垫具有明显的局部作用。本文讨论了该方法在男性长期生育调节中的可行性。
