O'Berg M T
J Occup Med. 1980 Apr;22(4):245-52.
This retrospective cohort study of 1,345 male employees with potential for exposure to acrylonitrile analyzes cancer incidence and mortality from 1956 to 1976. Expected numbers based on company and national rates have been computed on person-years. The analyses consider calendar time, payroll classification, occupation, duration of exposure, severity of exposure, and latency. Overall, 25 cases of cancer occurred, with 20.5 expected based on company rates. Of these, eight were respiratory cancer cases, with 4.4 expected. Excesses were found primarily during the 1970-76 time period among wage roll employees who had worked during plant start-up. A trend toward increased risks was seen with increased duration and severity of exposure. Twenty cancer deaths were found, with 17.4 expected according to company rates. Since many cancer cases were recently diagnosed and are living, it may be premature to evaluate mortality statistics. These findings, coupled with results from tests in laboratory animals, raise the serious suspicion that acrylonitrile may be a human carcinogen.
这项针对1345名有丙烯腈接触可能的男性员工的回顾性队列研究，分析了1956年至1976年期间的癌症发病率和死亡率。基于公司和国家发病率计算出的预期病例数已根据人年进行了计算。分析考虑了日历时间、工资分类、职业、接触持续时间、接触严重程度和潜伏期。总体而言，共发生了25例癌症病例，根据公司发病率预期为20.5例。其中，8例为呼吸道癌症病例，预期为4.4例。超额病例主要出现在1970 - 1976年期间，在工厂启动时工作的工资名册员工中。随着接触持续时间和严重程度的增加，风险呈现上升趋势。发现了20例癌症死亡病例，根据公司发病率预期为17.4例。由于许多癌症病例是最近才确诊且仍在世，评估死亡率统计数据可能为时过早。这些发现，再加上实验动物测试的结果，引发了人们对丙烯腈可能是人类致癌物的严重怀疑。
