Wood S M, Buffler P A, Burau K, Krivanek N
Research Administration Services, Walnut Creek, California, United States.
Scand J Work Environ Health. 1998;24 Suppl 2:54-62.
This study assessed the risk of cancer mortality and incidence among 2559 employees exposed to acrylonitrile in the production of Orlon at 2 plants in 1944-1991. Latency, duration of exposure, highest level of exposure ever experienced, and cumulative exposure were used as indicators of exposure. The average duration of exposure for the workers was 7.6 years with an average cumulative exposure of 57.6 ppm-years. Overall mortality was lower than expected in a comparison with the United States population and all DuPont employees [454 deaths, standardized mortality ratios (SMR) of 69 and 91, respectively)]. All the cancer death ratios were lower than expected in a similar comparison. The SMR values for specific sites did not differ significantly from the expected values. Mortality from all cancers and from prostate, respiratory, and digestive cancer did not show any significantly associated increases or a consistent pattern suggestive of a dose-response. The cancer morbidity patterns were similarly unremarkable.
本研究评估了1944年至1991年期间在两家工厂生产奥纶过程中接触丙烯腈的2559名员工的癌症死亡率和发病率风险。接触潜伏期、接触持续时间、曾经经历的最高接触水平以及累积接触量被用作接触指标。工人的平均接触持续时间为7.6年，平均累积接触量为57.6 ppm-年。与美国人群和所有杜邦员工相比，总体死亡率低于预期（分别为454例死亡，标准化死亡率（SMR）分别为69和91）。在类似比较中，所有癌症死亡率均低于预期。特定部位的SMR值与预期值无显著差异。所有癌症以及前列腺癌、呼吸道癌和消化道癌的死亡率均未显示出任何显著相关的增加或提示剂量反应的一致模式。癌症发病模式同样不显著。
