Swaen G M, Bloemen L J, Twisk J, Scheffers T, Slangen J J, Collins J J, ten Berge W F, Sturmans F
Department of Epidemiology, University of Maastricht, The Netherlands.
Scand J Work Environ Health. 1998;24 Suppl 2:10-6.
A retrospective cohort study investigating the cause-specific mortality patterns of 2842 workers occupationally exposed to acrylonitrile for at least 6 months before 1 July 1979 was updated. The comparison group consisted of 3961 workers from a nitrogen fixation plant during the same time interval. Industrial hygiene assessments quantified past exposure to acrylonitrile, the use of personal protective equipment, and exposure to other potential carcinogenic agents. All 6803 workers were followed for mortality until 1 January 1996. The follow-up was almost complete (99.6%), and for 99.3% the cause of death was ascertained. Age distribution, follow-up period, and temporal changes in background mortality rates were adjusted for in calculations of standardized mortality ratios for separate causes of death. Cumulative dose-effect relations were determined for 3 exposure categories and 3 latency periods. The results showed that, although cancer mortality fluctuated slightly, no cancer excess seems related to exposure to acrylonitrile.
一项回顾性队列研究对1979年7月1日前职业性接触丙烯腈至少6个月的2842名工人的死因别死亡率模式进行了更新。对照组由同一时间间隔内来自一家氮肥厂的3961名工人组成。工业卫生评估对过去接触丙烯腈的情况、个人防护设备的使用以及接触其他潜在致癌剂的情况进行了量化。对所有6803名工人进行了直至1996年1月1日的死亡率随访。随访几乎是完整的（99.6%），并且99.3%的死亡原因得以确定。在计算各死因的标准化死亡比时，对年龄分布、随访期以及背景死亡率的时间变化进行了调整。确定了3种接触类别和3个潜伏期的累积剂量-效应关系。结果显示，尽管癌症死亡率略有波动，但似乎没有癌症超额与接触丙烯腈有关。
