Farber M B, Ray D S
J Virol. 1980 Mar;33(3):1106-10. doi: 10.1128/JVI.33.3.1106-1110.1980.
A clear-plaque mutation (c2) of bacteriophage M13 has been shown to affect the regulation of viral DNA synthesis. This mutation increases the amount of the duplex replicative form DNA per cell while decreasing the synthesis of viral single strands. The relative synthesis of the M13 gene 5 protein is approximately half that observed in wild-type infections, suggesting that the effect of the c2 mutation on the regulation of viral DNA synthesis is a result of reduced expression of gene 5.
噬菌体M13的一种清晰噬菌斑突变（c2）已被证明会影响病毒DNA合成的调控。这种突变增加了每个细胞中双链复制型DNA的量，同时减少了病毒单链的合成。M13基因5蛋白的相对合成量约为野生型感染中观察到的一半，这表明c2突变对病毒DNA合成调控的影响是基因5表达降低的结果。
