Graham J M, Badura R J, Smith D W
Pediatrics. 1980 May;65(5):995-9.
A retrospective study of 11 instances of idiopathic coronal craniostenosis in otherwise normal children revealed that early lightening, prolonged moderate to severe pelvic discomfort late in pregnancy, and/or an abnormal fetal lie were unusual gestational features indicative of intrauterine constraint for eight of these patients. The impression of unusual constraint in utero was further implied by finding associated positional foot deformities in four of these latter eight children. We hypothesize that prolonged constraint of the fetal head may limit anteroposterior growth stretch at the coronal suture and thereby predispose toward early sutural fusion.
一项针对11例其他方面均正常的儿童特发性冠状缝早闭病例的回顾性研究表明，在这些患者中，有8例早期入盆、妊娠晚期出现持续的中度至重度骨盆不适和/或胎位异常是提示子宫内受限的异常妊娠特征。在这后8名儿童中的4名发现相关的位置性足部畸形，进一步暗示了子宫内存在异常受限的情况。我们推测，胎儿头部的长期受限可能会限制冠状缝处的前后生长伸展，从而易导致早期缝线融合。
