Baettig K, Martin J R, Classen W
Pharmacol Biochem Behav. 1980 Jan;12(1):107-11. doi: 10.1016/0091-3057(80)90423-2.
Rats chronically treated twice daily with nicotine (0.4 mg/kg, SC) or d,1-amphetamine (1.5 mg/kg, SC) exhibited different patterns of anorexia, hypodipsia, and body weight loss. Amphetamine-treated rats developed tolerance to these ingestive effects and to weight loss, whereas nicotine-injected rats did not. There was little, if any, evidence for cross-tolerance when the drugs were switched between the two groups. These results indicate that different mechanisms underlie the ingestive effects of nicotine and amphetamine.
每天两次对大鼠进行尼古丁（0.4毫克/千克，皮下注射）或d,1-苯丙胺（1.5毫克/千克，皮下注射）的慢性处理，结果显示出不同的厌食、饮水量减少和体重减轻模式。接受苯丙胺处理的大鼠对这些摄食效应和体重减轻产生了耐受性，而注射尼古丁的大鼠则没有。当在两组之间切换药物时，几乎没有（如果有的话）交叉耐受性的证据。这些结果表明，尼古丁和苯丙胺的摄食效应背后存在不同的机制。
