1-β-D-阿拉伯呋喃糖基胞嘧啶-5'-二磷酸-L-1,2-二棕榈酸酯的合成、表征及初步生物学评价 - Suppr

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The synthesis, characterization, and preliminary biological evaluation of 1-beta-D-arabinofuranosylcytosine-5'-diphosphate-L-1,2-dipalmitin.

作者信息

MacCoss M, Ryu E K, Matsushita T

出版信息

Biochem Biophys Res Commun. 1978 Nov 29;85(2):714-23. doi: 10.1016/0006-291x(78)91220-2.

DOI:10.1016/0006-291x(78)91220-2

PMID:736929

Abstract

摘要

相似文献

The synthesis, characterization, and preliminary biological evaluation of 1-beta-D-arabinofuranosylcytosine-5'-diphosphate-L-1,2-dipalmitin.1-β-D-阿拉伯呋喃糖基胞嘧啶-5'-二磷酸-L-1,2-二棕榈酸酯的合成、表征及初步生物学评价

Biochem Biophys Res Commun. 1978 Nov 29;85(2):714-23. doi: 10.1016/0006-291x(78)91220-2.

Phospholipid-nucleoside conjugates. 3. Syntheses and preliminary biological evaluation of 1-beta-D-arabinofuranosylcytosine 5'-monophosphate-L-1,2-dipalmitin and selected 1-beta-D-arabinofuranosylcytosine 5-diphosphate-L-1,2-diacylglycerols.磷脂 - 核苷缀合物。3. 1-β-D-阿拉伯呋喃糖基胞嘧啶5'-单磷酸 - L-1,2-二棕榈酸酯及选定的1-β-D-阿拉伯呋喃糖基胞嘧啶5-二磷酸 - L-1,2-二酰基甘油的合成与初步生物学评价。

J Med Chem. 1982 Nov;25(11):1322-9. doi: 10.1021/jm00353a010.

Phospholipid derivatives of nucleoside analogs as prodrugs with enhanced catabolic stability.作为具有增强分解代谢稳定性的前药的核苷类似物的磷脂衍生物。

Cancer Res. 1981 Jul;41(7):2707-13.

Cytotoxic liponucleotide analogs. I. Chemical synthesis of CDP-diacylglycerol analogs containing the cytosine arabinoside moiety.细胞毒性脂核苷酸类似物。I. 含阿糖胞苷部分的CDP - 二酰甘油类似物的化学合成。

Biochim Biophys Acta. 1980 Sep 8;619(3):604-18. doi: 10.1016/0005-2760(80)90110-1.

Cytotoxic liponucleotide analogs. II. Antitumor activity of CDP-diacylglycerol analogs containing the cytosine arabinoside moiety.细胞毒性脂核苷酸类似物。II. 含有阿糖胞苷部分的CDP - 二酰甘油类似物的抗肿瘤活性。

Biochim Biophys Acta. 1980 Sep 8;619(3):619-31. doi: 10.1016/0005-2760(80)90111-3.

Preparation and antitumor activity of 4'-thio analogs of 2,2'-anhydro-1-beta-D-arabinofuranosylcytosine.2,2'-脱水-1-β-D-阿拉伯呋喃糖基胞嘧啶4'-硫代类似物的制备及其抗肿瘤活性

J Med Chem. 1974 May;17(5):535-7. doi: 10.1021/jm00251a015.

Evaluation of the conjugate between N4-(4-carboxybutyryl)-1-beta-D-arabinofuranosylcytosine and chitosan as a macromolecular prodrug of 1-beta-D-arabinofuranosylcytosine.N4-(4-羧基丁酰基)-1-β-D-阿拉伯呋喃糖基胞嘧啶与壳聚糖的缀合物作为1-β-D-阿拉伯呋喃糖基胞嘧啶的大分子前药的评价。

Drug Des Discov. 1993;10(4):343-53.

Formation of 1-beta-D-arabinofuranosylcytosine diphosphate choline in cultured human leukemic RPMI 6410 cells.1-β-D-阿拉伯呋喃糖基胞嘧啶二磷酸胆碱在培养的人白血病RPMI 6410细胞中的形成。

Cancer Res. 1978 Jun;38(6):1723-9.

Synthetic nucleosides and nucleotides. XVI. Synthesis and biological evaluations of a series of 1-beta-D-arabinofuranosylcytosine 5'-alkyl or arylphosphates.合成核苷与核苷酸。十六。一系列1-β-D-阿拉伯呋喃糖基胞嘧啶5'-烷基或芳基磷酸酯的合成与生物学评价。

Chem Pharm Bull (Tokyo). 1980 Oct;28(10):2915-23. doi: 10.1248/cpb.28.2915.

Synthesis of a new potent antitumor nucleoside, 2'-C-cyano-2'-deoxy-1-beta-D- arabinofuranosylcytosine.一种新型强效抗肿瘤核苷2'-C-氰基-2'-脱氧-1-β-D-阿拉伯呋喃糖基胞嘧啶的合成。

Nucleic Acids Symp Ser. 1990(22):51-2.

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