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Membrane-permeable tenofovir-di- and monophosphate analogues.
Eur J Med Chem. 2024 Jan 15;264:116020. doi: 10.1016/j.ejmech.2023.116020. Epub 2023 Dec 11.
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Synthesis and Characterization of NUC-7738, an Aryloxy Phosphoramidate of 3'-Deoxyadenosine, as a Potential Anticancer Agent.
J Med Chem. 2022 Dec 8;65(23):15789-15804. doi: 10.1021/acs.jmedchem.2c01348. Epub 2022 Nov 23.
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Microwave-assisted organic synthesis of nucleoside ProTide analogues.
RSC Adv. 2019 Jun 27;9(35):20113-20117. doi: 10.1039/c9ra01754b. eCollection 2019 Jun 25.
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The Novel Nucleoside Analogue ProTide NUC-7738 Overcomes Cancer Resistance Mechanisms and in a First-In-Human Phase I Clinical Trial.
Clin Cancer Res. 2021 Dec 1;27(23):6500-6513. doi: 10.1158/1078-0432.CCR-21-1652. Epub 2021 Sep 8.
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An overview of ProTide technology and its implications to drug discovery.
Expert Opin Drug Discov. 2021 Oct;16(10):1149-1161. doi: 10.1080/17460441.2021.1922385. Epub 2021 May 24.
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Remdesivir for the Treatment of Covid-19 - Final Report.
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Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations.
Molecules. 2018 Jul 14;23(7):1719. doi: 10.3390/molecules23071719.
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Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues.
Angew Chem Int Ed Engl. 2016 Apr 18;55(17):5255-8. doi: 10.1002/anie.201511808. Epub 2016 Mar 23.
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Tenofovir alafenamide: A novel prodrug of tenofovir for the treatment of Human Immunodeficiency Virus.
Antiviral Res. 2016 Jan;125:63-70. doi: 10.1016/j.antiviral.2015.11.009. Epub 2015 Nov 27.
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Bis(benzoyloxybenzyl)-DiPPro nucleoside diphosphates of anti-HIV active nucleoside analogues.
ChemMedChem. 2015 May;10(5):891-900. doi: 10.1002/cmdc.201500063. Epub 2015 Apr 2.

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