Steen P A, Milde J H, Michenfelder J D
Anesthesiology. 1980 Mar;52(3):224-30. doi: 10.1097/00000542-198003000-00007.
The authors had previously observed a deleterious cerebrovascular effect of prolonged hypothermia in primates and cats. In this study they examined the systemic as well as cerebral hemodynamic and metabolic effects of 24 hours of hypothermia in the dog. With decreases in temperature to 29 C, cardiac output (Q) and whole-body oxygen consumption (VO2) initially decreased 52 and 42 per cent, respectively. Thereafter, despite a stable temperature, both Q and VO2 continued to decrease, and at 24 hours values were 7 and 28 per cent of control, respectively, Cerebral blood flow (CBF) and cerebral oxygen consumption responded similarly. At 24 hours inhomogeneous perfusion of both brain and skeletal muscle was observed. With rewarming, cardiovascular collapse with severe tissue hypoxia and acidosis developed; CBF became grossly inadequate, resulting in depletion of brain energy stores.
作者们之前曾观察到，长时间低温对灵长类动物和猫的脑血管有有害影响。在本研究中，他们检测了犬只24小时低温下的全身以及脑部血流动力学和代谢效应。随着体温降至29摄氏度，心输出量（Q）和全身耗氧量（VO2）最初分别下降了52%和42%。此后，尽管体温稳定，但Q和VO2仍继续下降，24小时时的值分别为对照组的7%和28%。脑血流量（CBF）和脑耗氧量也有类似反应。24小时时，观察到脑和骨骼肌灌注不均匀。复温时，出现了伴有严重组织缺氧和酸中毒的心血管衰竭；CBF严重不足，导致脑能量储备耗竭。
