Phenytoin shortens the half-life of the hypoxic cell radiosensitizer misonidazole in man: implications for possible reduced toxicity.
作者信息
Workman P, Bleehen N M, Wiltshire C R
出版信息
Br J Cancer. 1980 Feb;41(2):302-4. doi: 10.1038/bjc.1980.43.
Abstract
摘要
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Phenytoin shortens the half-life of the hypoxic cell radiosensitizer misonidazole in man: implications for possible reduced toxicity.苯妥英钠可缩短人体中缺氧细胞放射增敏剂米索硝唑的半衰期：对可能降低毒性的意义。
Br J Cancer. 1980 Feb;41(2):302-4. doi: 10.1038/bjc.1980.43.
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Effects of pretreatment with phenobarbitone and phenytoin on the pharmacokinetics and toxicity of phenytoin on the pharmacokinetics and toxicity of misonidazole in mice.苯巴比妥和苯妥英预处理对苯妥英在小鼠体内药代动力学及米索硝唑毒性的影响。
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Misonidazole blood and cerebrospinal fluid kinetics in monkeys following intravenous and intrathecal administration.
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Plasma concentrations and pharmacokinetics of misonidazole after intraperitoneal administration to the mouse.腹腔注射给予小鼠后米索硝唑的血浆浓度及药代动力学
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Plasma concentrations of misonidazole.米索硝唑的血浆浓度。
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Kinetic aspects of misonidazole and its major metabolite in radiotherapy.米索硝唑及其主要代谢物在放射治疗中的动力学研究
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引用本文的文献
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Radiosensitisers.放射增敏剂
Br Med J. 1980 Oct 25;281(6248):1089-90.
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Phenytoin-induced changes in the pharmacokinetics of misonidazole in radiotherapy patients.苯妥英钠对放疗患者米索硝唑药代动力学的影响。
Br J Cancer. 1981 Oct;44(4):592-6. doi: 10.1038/bjc.1981.232.
3
A comparative investigation of nimorazole and misonidazole as hypoxic radiosensitizers in a C3H mammary carcinoma in vivo.硝唑咪和米索硝唑作为体内C3H乳腺癌低氧放射增敏剂的比较研究。
Br J Cancer. 1982 Dec;46(6):904-11. doi: 10.1038/bjc.1982.300.
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Pharmacokinetic interactions with antiepileptic drugs.与抗癫痫药物的药代动力学相互作用。
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Drug interactions with phenytoin.与苯妥英钠的药物相互作用。
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No significant effect of cimetidine on the pharmacokinetics of misonidazole in man.西咪替丁对人咪硝唑药代动力学无显著影响。
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No significant effect of metoclopramide on misonidazole elimination in man.胃复安对人体内灭滴灵的清除没有显著影响。
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The role of dexamethasone in the modification of misonidazole pharmacokinetics.地塞米松在改变米索硝唑药代动力学中的作用。
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Pharmacokinetic drug interactions with phenytoin (Part II).苯妥英的药代动力学药物相互作用（第二部分）。
Clin Pharmacokinet. 1990 Feb;18(2):131-50. doi: 10.2165/00003088-199018020-00004.
本文引用的文献
1
Pharmacological implications of microsomal enzyme induction.微粒体酶诱导的药理学意义。
Pharmacol Rev. 1967 Sep;19(3):317-66.
2
Hypoxic sensitizers: radiobiological studies at the cellular level.缺氧敏化剂：细胞水平的放射生物学研究
Radiology. 1975 Nov;117(2):453-7. doi: 10.1148/117.2.453.
3
Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses.放射增敏剂Ro 07-0582的临床试验：多次给药的经验
Br J Cancer. 1977 May;35(5):567-79. doi: 10.1038/bjc.1977.90.
4
Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring.监测人体唾液中的米索硝唑：血浆监测的一种可能替代方法。
Br J Cancer. 1978 Dec;38(6):709-18. doi: 10.1038/bjc.1978.277.
5
The toxicity of the radiosensitizer misonidazole towards hypoxic cells in vitro: a model for mouse and man.
Br J Radiol. 1978 Sep;51(609):745-6. doi: 10.1259/0007-1285-51-609-745.
6
Liver size and indices of drug metabolism in epileptics.癫痫患者的肝脏大小及药物代谢指标
Br J Clin Pharmacol. 1978 Sep;6(3):273-8. doi: 10.1111/j.1365-2125.1978.tb04597.x.
7
Estimation of the hypoxic cell-sensitiser misonidazole and its O-demethylated metabolite in biological materials by reversed-phase high-performance liquid chromatography.采用反相高效液相色谱法测定生物材料中乏氧细胞增敏剂米索硝唑及其O-去甲基代谢物。
J Chromatogr. 1978 May 1;145(3):507-12. doi: 10.1016/s0378-4347(00)81386-9.
8
Effects of pretreatment with phenobarbitone and phenytoin on the pharmacokinetics and toxicity of phenytoin on the pharmacokinetics and toxicity of misonidazole in mice.苯巴比妥和苯妥英预处理对苯妥英在小鼠体内药代动力学及米索硝唑毒性的影响。
Br J Cancer. 1979 Sep;40(3):335-53. doi: 10.1038/bjc.1979.187.
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Distribution of misonidazole in human tumours and normal tissues.米索硝唑在人体肿瘤组织和正常组织中的分布。
Br J Cancer. 1979 May;39(5):503-9. doi: 10.1038/bjc.1979.93.
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